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In Louisiana, Botox injections are considered medical procedure and must be performed by a licensed physician, a physician assistant under physician delegation and supervision if it is beyond their scope of practice, or a nurse practitioner working under a joint practice arrangement with the physician if it is beyond their scope of practice.

The physician can delegate this procedure to a non-physician (registered nurses, licensed practical nurses, or unlicensed personnel) if they have at least the following knowledge and training: [1] safety and application techniques, [2] cutaneous medicine, [3] indications/contraindications for this procedure, [4] preoperative and post-operative care, and [4] potential complications and infectious diseases.